A photograph of Dr. Jean Theberge
Jean Théberge
He, Him, His
PhD, FCCPM
Scientist, Lawson Health Research Institute
Physicist, St. Joseph's Health Care London
Associate Professor, Medical Imaging, Medical Biophysics and Psychiatry, Western University
Director, Biomedical Imaging Research Center
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NeuroPIL - The NeuroPsychiatry Imaging Lab

Who We Are, What we do

The NeuroPIL, lead by Dr. Jean Théberge, is a research group dedicated to the development, implementation and application of brain imaging methodologies in psychiatry research.

Biography

My interest in medical physics stems from my original interest in numerical physics during my undergraduate degree in physics where I participated to a project developing automated analysis methods for radiographic images of breast calcifications.

I pursued my interest in medical physics embarking in a master's degree from Université de Montréal under the supervision of Gilles Beaudoin, a medical physicist from Notre-Dame Hospital in Montréal. Throughout this project, I gained a solid basis in MR physics and practical aspects of MRI, fMRI and pulse sequence development on a clinical scanner. The core research of my master's degree consisted in the implementation of fast MRI methods for mapping water apparent diffusion coefficients. Concurrently, I received a general formation in medical physics through the core courses of the medical physics graduate program of McGill University (physics of diagnostic radiology, nuclear medicine, radiation physics).

I then moved on to the University of Western Ontario to pursue a Ph.D. in Medical Biophysics. My supervisors were Dr. Dick Drost and Dr. Peter Williamson, well respected experts in the field of magnetic resonance and psychiatry research. My thesis project involved work with schizophrenia patients and familiarization with spectroscopy (MRS), an entirely different sub-specialty of magnetic resonance, while using the only 4.0 Tesla whole-body MR scanner in Canada at the time. My doctorate work included a clinical application aspect (protocol development, data acquisition and schizophrenia research) and a technical aspect (development of MRS methodology and data processing).

Clinical applications concentrated on the study of various populations of patients with schizophrenia. I conducted five studies and participated to several others. The most unique study certainly is my longitudinal study of first episode patients with schizophrenia studied before antipsychotic treatment, after stabilization with medication and after thirty months of treatment using high field MRS to measure glutamatergic metabolites in candidate brain circuits simultaneously with reductions in gray matter volume. The five studies resulted in publications in American Journal of Psychiatry (2) and in Psychiatry Research - Neuroimaging (2). The last study was a multi-year project completed months after the defense of my thesis. This study is currently being submitted to the British Journal of Psychiatry.

The technical work has focused on MRS pulse sequence development aimed at improving the quantification of brain metabolites of interest in mental illnesses. Most of my technical work involved the use of the Stimulated Echo Acquisition Mode (STEAM) pulse sequence, especially its use at very short echo times and small region of interest. I conducted two studies related to this work. This has led to one publication in Magnetic Resonance in Medicine and another manuscript still awaiting submission.

I completed my Ph.D. in September 2004 and have then joined the Brain Imaging Center of McLean Hospital (Belmont, MA, USA) as a research fellow in the department of psychiatry at Harvard Medical School. I worked under the supervision of Dr. Perry Renshaw and in collaboration with several investigators of McLean Hospital. My research activities have been divided between the implementation of arterial spin labeling MRI methods on a 3.0 Tesla Siemens system to study mood disorders, drug abuse and neurological effects of diabetes and the implementation of proton, fluorine and phosphorus MRS methods on a 4.0 Tesla Varian scanner to study the treatment of depression and schizophrenia.

After a year and half as a postdoctoral fellow at McLean Hospital, I was promoted to the level of instructor and recommended to be fast-tracked to assistant professor level. During my postdoctoral fellowship, I have applied for funding of my own in order to pursue research in schizophrenia and have obtained fellowship award from the Canadian Institutes of Health Research to design novel MRS techniques to measure brain levels of serine, a naturally occurring amino acid, currently being tested as a supplement (D-serine) to antipsychotic medication which improves negative and cognitive symptoms of schizophrenia by its action on the glutamatergic receptors.

Since November 2006, I have begun work at St. Joseph's Health Care as a medical physicist in the Department of Nuclear Medicine and MR. I have also obtained a research affiliation with the Lawson Health Research Institute as a principal investigator and an academic appointment with the department of diagnostic radiology and nuclear medicine of UWO. I plan to actively pursue research in the field of magnetic resonance and neuropsychiatry. With the help of graduate students, I will continue to develop medical imaging methodologies that keep our neuropsychiatry research program ahead of the competition.

Research funding (Non-exhaustive)

NSERC Logo

NSERC

Discovery Grants

  • 2021-2026 "Determinants of brain glutamate functional magnetic resonance spectroscopy response"
  • 2015-2021 "Optimizing detection of glutamate functional magnetic resonance spectroscopy signals in the human brain"
  • 2010-2015 "Unravelling the origins of glutamatergic magnetic resonance spectroscopy signals in the human brain"

 

CIHR Logo

CIHR

Team Grants

  • 2021-2022 "Cognitive decline in type 2 diabetes (DiCog Study)" (Co-PI)
  • 2020-2023 "A randomized control trial of a novel approach to cognitive training in public safety personnel with post traumatic stress injuries" (Co-I)

Foundation Grants

  • 2017-2022 "Origins, Consequences and Outcomes of Neuroprogression in First Episode Schizophrenia" (Co-I)

Project Grants

  • 2023-2028 "Understanding the Effects of Adolescent Nicotine Exposure on Increased Risk of Mood and Anxiety Disorders: Bridging the Gap from Pre-Clinical to Clinical Investigations" (Co-App)
  • 2022-2024 "Regulating post-traumatic stress disorder neural networks: A real-time fMRI neurofeedback mechanistic study in frontline healthcare workers" (Co-I)
  • 2017-2022 "Myeling Mapping and Negative Symptoms of Schizophrenia" (Co-App)
Citation Report Graph

Productivity Indices

(Google Scholar June 30th 2026)

First Publication year: 2002

H-Index: 55

Number of publications: 238

Number of Citations: 10804

See lists of publications associated with research themes below and full publication list on the profile links above (Google Scholar, PubMed, etc.)

Théberge CFI-LOF Infrastructure - Lawson Imaging 3.0 Tesla fMRI Facility

 

Item 1 – PET-MRI Hardware Package

32-Ch Ceresensa Head Coil

Item 1a - 32-channel Brain RF arry prospectively designed for simultaneous PET-MRI.

Manufacturer: Ceresensa

Model: KMV1

Operating Frequency: 123.8 MHz

Internal dimensions: 21.2cm x 24.4cm

RF Front End: Receive-only

Number of independent channels: 32

Operating Modes: bottom half, top half, both halves

Notable Features: Minimal attenuation of PET gamma rays (~2%)

Item 2 – Functional Paradigm Delivery and Monitoring Package

ProPixx Projector

Item 2a – MRI Compatible Projector.

Manufacturer: VPixx Technologies Inc.

Model: ProPixx with SHIELDPixx

Refresh Rate: 500 Hz (RGB), 1440Hz (Greyscale)

Display Resolution: 1920(H) x 1080(V) pixels

Aspect Ratio: 16x9

Illumination system: RGB LED

Contrast ratio: 2000:1

Lens: super long-throw lens (VPX-ACC-6505, throw ratio 5.6-9.9:1)

Screen: DA-LITE Custom rear projection screen

3D capability: VPIXX 3D circular polarizing filter (with 4 pairs of passive glasses).

fORP8-fiber bundle4-button diamond5-button diamondtwo-handed buttonsstick buttonsScroll button

Item 2b – MRI Compatible fiber optic response pad system.

Manufacturer: Current Designs.

Model: fORP

Interface: FIU-932

Fiber: 12-fiber, 55’

Devices:

 HHSC-1x4-D  (4-button Diamond pattern)

 TR-1x4-D     (4-button Diamond trainer, not MR compatible)

 HHSC-1x5-D  (5-button Diamond pattern)

 HHSC-1x5-CYL (5 button cylinder)

 HHSC-SCRL-1 (scroll click)

 HHSC-2x4-L   (bimanual 4-button line pattern) 

ShieldPixx audio system

Item 2c – MRI Compatible audio system.

Manufacturer: VPixx Technologies.

Model: SHIELDPixx

Interface: audio line in, mic in, speaker out (3.5mm jack)

 

TRACKPixx frontTRACKPixx Back

 

Item 2d – MRI Compatible Camera (eye monitoring)

Manufacturer: VPixx Technologies.

Model: TRACKPixx

 

 

Powerlab 4/35

Item 2e – Digitization system for patient monitoring signals

Manufacturer: AD Instruments.

Model: PowerLab 4/35

Software: LabChart Pro

 

Item 3 – Data Analysis and Archival Package

Dell Workstations

Item 3a – Data Analysis Workstation

Manufacturer: Dell

Model: Precision T7610 Workstation

CPU: Intel Xeon E5-2687W v2 8-cores HT, 3.4GHz

Memory: 32Gb 1866MHz DDR3 ECC RDIMM

Storage: 4 x 1TB 7200rpm SATA Hard Drives

GPU: 3GB NVidia Quadro K4000 (768 CUDA cores)

Software: Windows 7

UPS: Smart UPS 750VA LCD 120V

Monitor: Dell UltraSharp 24

BD-R

Item 3b – Data Archival System

Manufacturer: Compudata

Model: LG BH16NS40 Super Multi Blue

Format: BD-RE – 14x2x12x – Serial ATA

Enclosure: Vantec NexStar DX

Interface: USB3.0

Media: M-disks (BD-R TL – 100GB)

 

Item 4 – Extended Service and Warranty

 

Item 4a – 4-year Head Coil Extended Warranty for item 1

 

Item 4b – 4-year Head Coil Extended Warranty for item 2d

 

Other Computing Equipment

HP Z820

Description: 2 number crunching workstations

Manufacturer: HP

Model: Z820

CPU: Intel Xeon 8-cores HT, 3.3GHz

Memory: 16Gb DDR3 ECC

Storage: 500GB HDD, 1TB HDD

GPU: 2 x NVididia Tesla C2075 (448 CUDA cores)

Software: Windows 10 Pro

Monitor: Dell 19"

 

Théberge fMRI facility equipment purchased with Start Up Funds in 2006

Audio source

 Cambridge Soundworks

 

Cambridge Soundworks 765i – part of RTI Serene Sound system. Used as basic audio/video source and audio monitor.

Audio inputs: Am/FM radio, CD, iPod, Aux

Audio outputs: lineout (3.5mm stereo jack), Headphone (3.5mm).

Video inputs: DVD,CD-ROM, DVD-ROM

Video outputs: s-video, composite

Web site: http://store.cambridgesoundworks.com/

Sound system and communication

SereneSound

RTI SereneSound Headset

Used for protocols requiring high fidelity audio stimuli.

30dB attenuation of gradient noises

40Hz to 40kHz frequency response.

Slim profile for use with Siemens 32-channel head coil.

Website: http://www.mrivideo.com/product/fmri/as.htm

MR Compatible Eyeglasses

MediGoggles

 

Cambridge Research Systems Medigoggles. MR-compatible interchangeable prescription eyeglass with lens inserts in Rx powers from -6 to +6 dioptre in 0.5 dioptre increments.

 

Website: www.crsltd.com/medigoggles

Screens & Mirror

Screens

Two configurations of projection screen are available:

  1. Rear projection setup using LCD projector in equipment room projecting via large wave guide onto mirror which reflects into back of scanner bore where custom rear projection screen is positioned. The screen fits within 1cm of the 70cm diameter bore of the scanner.
  2. Rear projection setup where a large semi-transparent screen is placed between control area and scanner. Projector sits outside scanner room and projects through RF window. (this impedes direct line of sight with subject)

Projector

 

InFocus IN1502

InFocus IN5102 LCD projector.

Native resolution is 1024x768 (XGA). 4000 Lumens.

Lens: standard and ultra-long throw (LENS-040)

Permanently mounted in equipment room.

XGA connection and video signal amplifier available in control room.

Website: http://www.infocus.com/Products/Projectors/IN5102.aspx 

 

 

Lab Theses

  1. Théberge, Jean. (2004) “Short echo time proton magnetic resonance spectroscopy in the study of schizophrenia”, Ph.D. thesis, University of Western Ontario, Medical Biophysics, London, Ontario, Canada. [PDF]
  2. Gagnon, Yann. (2013) "Magnetic Resonance Imaging of Brain Tissue Abnormalities: Transverse Relaxation Time in Autism and Tourette Syndrome and Development of a Novel Whole-Brain Myelin Mapping Technique", Ph.D. thesis, University of Western Ontario, Medical Biophysics, London, Ontario, Canada. [PDF]
  3. Taylor, Reggie. (2015) "Resting and Functional Magnetic Resonance Spectroscopy of Glutamate in Schizophrenia at 7 Tesla", Ph.D. Thesis, University of Western Ontario, Medical Biophysics, London, Ontario, Canada. [PDF]
  4. Javadzadeh, Homa (2016) "Measuring Brain Serine with Proton Magnetic Resonance Spectroscopy at 3.0 Tesla", M.Sc. thesis, University of Western Ontario, London, Ontario, Canada [PDF]
  5. Jeon, Peter (2019) "Functional magnetic Resonance Spectroscopy in First-Episode Schizophrenia Measuring Glutamate and glutathione Dynamics at 7-Tesla", M.Sc. thesis, University of Western Ontario, Medical Biophysics, London, Ontario, Canada [PDF]
  6. Farag, Adam H.  (2020) "Improving Hybrid PET/MRI Cardiovascular Imaging with Improved Hardware Design and Attenuation Correction Coefficient", Ph.D. thesis, University of Western Ontario, Medical Biophysics, London, Ontario, Canada [PDF].
  7. Jeon, Peter Y. (2024) "Investigating Oxidative Stress in Early Stages of Schizophrenia Using 7-Tesla Glutathione and Glutamate Functional Magnetic Resonance Spectroscopy", Ph.D. Thesis, Medical Biophysics, London, Ontario, Canada [PDF]

Awards

Photo of award plaque

2019

Western University Department of medical Imaging Annual Award for Academic Execellence in Research

Photo of award plaque

2020

World Discoveries Vanguard Awards for Licence Agreement Signed.

Photo of award plaque

2023

Canadian Organization of Medical Physics

2023 Michael S. Pattersion Publication Impact Prize in Medical Physics

Most cited article by a member of COMP in the last 10 years

Land Acknowledgement

I acknowledges that my lab, the Lawson Health Research Institute and  Western University are located on the traditional territories of the Anishinaabek, Haudenosaunee, Lūnaapéewak and Chonnonton Nations, on lands connected with the Dish with One Spoon Covenant Wampum and the London Township and Sombra Treaties of 1796. As a descendent of the first settlers of New France, I have benefitted from the settler-colonial interpretation of these Treaties. This land continues to be home to diverse Indigenous peoples (First Nations, Métis and Inuit) whom I recognize as contemporary stewards of the land and vital contributors of our society. As a neuropsychiatry scientist at St. Joseph`s Health Care, I acknowledge that colonial approaches to medical research and mental health care have excluded and exploited Indigenous people. I recognize that the Indigenous people in Canada experience mental health and addictions at rates that are more than double those among non-Indigenous people. Suicide rates among Indigenous youth are more than 5 times higher than among non-Indigenous youth. The concept of Biigajiiskaan particularly resonates with me as a culturally-safe and accessible approach to wellness and renewal that I feel is a responsible way of engaging with Indigenous communities for our mutual benefit, wellness and prosperity.

Current Research Themes

Metabolite-selective MRS methodologies

Example of DANTE Pulse Sequence Diagram

Overview

Brief Description: Development, implementation, testing and application of proton MRS sequences isolating signals from specific brain metabolites, specifically DANTE-PRESS, a localized MRS pulse sequence using a very narrowband refocussing pulse in a triple spin echo approach.
Objective: Use the MRI manufacturer's pulse sequence development tools to implement the DANTE-PRESS pulse sequence and use it to obtain signals from human brain metabolites previously not accessible at this degree of precision using traditional MRS methodologies.
Fund: Lawson Internal Research Fund (JT), NSERC Discovery (JT). Collaborators: Siemens Healthineers and Lena Palaniyappan (Psychiatry).

Publications

  1. Kanagasabai K, Oran O, Palaniyappan L, Théberge J. Development and in vivo proof-of-concept of delayed alternating nutation tailored excitation point resolved spectroscopy (dante-press): a frequency-selective single voxel spectroscopy sequence applied to in vivo measurements of naa and glu at 7.0 T. MAGMA. 2026 May 16. doi: 10.1007/s10334-026-01365-4. Epub ahead of print. PMID: 42142295.
  2. Kanagasabai K, Palaniyappan L, Théberge J. Precision of metabolite-selective MRS measurements of glutamate, GABA and glutathione: A review of human brain studies. NMR Biomed. 2024 Mar;37(3):e5071. doi: 10.1002/nbm.5071. Epub 2023 Dec 4. PMID: 38050448. 

Abstracts and Proceedings

  1. Kanagasabai K, Oran O, Palaniyappan L, Theberge J. Double-DANTE PRESS: a multi-metabolite-selective 1H-MRS sequence for human brain measurements of glutamate and glutathione at 7T. In: Proceedings of the ISMRM & ISMRT Annual Meeting and Exhibition, Honolulu (USA), 2025, Abstract 2915.
  2. Javadzadeh H, Theberge J. Assessment of serine quantification reproducibility
    using advanced 1H-MRS in the human brain. In: Proceedings of the 24th Annual
    Meeting of ISMRM, Singapore, 2016 (Abstract 2381).
  3. Javadzadeh H. Théberge J. 1H-MRS measurement of serine in phantoms and
    demonstration in the human brain at 3.0 Tesla. In: Proceedings of the 23rd Annual
    Meeting of ISMRM, Toronto, Canada, 2015 (Abstract 5729).
  4. Javadzadeh H. Théberge J. 3.0 Tesla 1H-MRS measurements of human brain serine. In:
    Proceedings of the 22nd Annual Meeting of ISMRM, Milan, Italy, 2014 (Abstract 2139).
  5. Theberge J, Renshaw PF. In vivo measurements of brain serine with 1H-MRS. In:
    Proceedings of the 15th Annual Meeting of ISMRM, Berlin, Germany, 2007
    (Abstract 1373).

Theses

  1. Javadzadeh, Homa, "Measuring Brain Serine With Proton Magnetic Resonance Spectroscopy At 3.0 Tesla" (2016). Western Univiersity. Electronic Thesis and Dissertation Repository. 4344. [PDF]

Functional MRS of Human Brain Glutamate

Glu_fMRS_timecourse

Overview

Brief Description: Development of functional MRS paradigms. Objective: Examine the dependence of glutamatergic metabolites signals on brain activity in healthy human brains for applications in studies of patients with schizophrenia. Funding: OMHF NIF (JT), NSERC (JT), CIHR (LP). Collaborators: Lena Palaniyappan (Psychiatry)

Publications

  1. Graham JWC, Jeon P, Théberge J, Palaniyappan L. Non-linear variations in glutamate dynamics during a cognitive task engagement in schizophrenia. Psychiatry Res Neuroimaging. 2023 Jul;332:111640. doi: 10.1016/j.pscychresns.2023.111640. Epub 2023 Apr 10. PMID: 37121089.
  2. Taylor R, Neufeld RW, Schaefer B, Densmore M, Rajakumar N, Osuch EA, Williamson PC, Théberge J. Functional magnetic resonance spectroscopy of glutamate in schizophrenia and major depressive disorder: anterior cingulate activity during a color-word Stroop task. NPJ Schizophr. 2015 Sep 16;1:15028. doi: 10.1038/npjschz.2015.28. PMID: 27336037; PMCID: PMC4849454.
  3. Taylor R, Schaefer B, Densmore M, Neufeld RW, Rajakumar N, Williamson PC, Théberge J. Increased glutamate levels observed upon functional activation in the anterior cingulate cortex using the Stroop Task and functional spectroscopy. Neuroreport. 2015 Feb 11;26(3):107-12. doi: 10.1097/WNR.0000000000000309. PMID: 25536234; PMCID: PMC4323558.

Abstracts and Proceedings

  1. Jeon P, MacKinley M, Dempster K, Wong D, Palaniyappan L, Theberge J. (2021). Glutamatergic responses to a color-word Stroop task in first-episode schizophrenia: A 7-Tesla functional MRS study. Proceedings of the International Society for Magnetic Resonance in Medicine. ISMRM 2021 Annual Meeting & Exhibition, Virtual, Conference Date: 2021/5.
  2. Taylor R, Schaefer B, Neufeld RWJ, Williamson PC, Théberge J. Glutamatergic changes detected upon functional activation with a Stroop Task in healthy controls and in subjects with schizophrenia, Joint Annual Meeting ISMR-ESMRMB 2014, Milan, Italy, 10-16 May 2014, abstract #3780.
  3. Taylor R., Williamson P.C., Théberge J. Functional MRS in the Anterior Cingulate. International Society for Magnetic Resonance Imaging Meeting. Melbourne, Australia, May 5-11, 2012.
  4. Taylor R, Théberge J, Williamson PC. “Simulating human brain glutamate fMRS at 7.0T to determine minimum SNR requirements”- ISMRM, Stockholm, Sweden, May 2010. Abstract #907.

Theses

  1. Taylor, Reggie. (2015) "Resting and Functional Magnetic Resonance Spectroscopy of Glutamate in Schizophrenia at 7 Tesla", Ph.D. Thesis, University of Western Ontario, Medical Biophysics, London, Ontario, Canada.[PDF]
  2. Jeon, Peter (2019) "Functional magnetic Resonance Spectroscopy in First-Episode Schizophrenia Measuring Glutamate and glutathione Dynamics at 7-Tesla", M.Sc. Thesis, Western University, Medical Biophysics, London, Ontario, Canada[PDF]
  3. Jeon, Peter (2024) "Investigating Oxidative STress in Early Stages of Schizophrenia Using 7-Tesla Glutathione and Glutamate Functional Magnetic Resonance Spectroscopy", Ph.D. Thesis, Western University, London, Ontario, Canada. [PDF]

Real-Time fMRI Neurofeedback in PTSD

32chHead Coil_and_Cardiac_Coil

Overview

Brief Description: Use BOLD fMRI signals of the human brain fed back to human participants via visual scale to give participants the opportunity to control on their own brain activity level in selected regions of interest. Objective: Allow patients with PTSD to down-regulate the amount of activity of brain networks related to threat-detection, which are typically overactive in this condition. Fund: CIHR operating grant (Lanius). Collaborator: Ruth Lanius (Psychiatry, Western), Andrew Nicholson (Psychiatry & Behavioral Neurosciences, McMaster). My role: Co-applicant.

Publications

  1. Lieberman JM, Brady B, Lanius RA, Ros T, Théberge J, Frey BN, Bhat V, Scharnowski F, Nicholson AA. Longitudinal mapping of a randomized controlled trial of EEG neurofeedback in PTSD: Early symptom stabilization and implications for adjunctive therapeutic potential. Psychiatry Res Neuroimaging. 2026 Sep;361:112244. doi: 10.1016/j.pscychresns.2026.112244. Epub 2026 May 6. PMID: 42218852.
  2. Narikuzhy S, Harricharan S, Rabellino D, Densmore M, Théberge J, Lieberman J, McKinnon MC, Nicholson AA, Lanius RA. Bridging the self to the world: resting-state functional connectivity of the temporoparietal junction in post-traumatic stress disorder and its dissociative subtype. Neuroimage Clin. 2026;49:103920. doi: 10.1016/j.nicl.2025.103920. Epub 2025 Dec 2. PMID: 41496380; PMCID: PMC12811541.
  3. Lieberman JM, Lanius RA, Densmore M, Théberge J, Rabellino D, Frewen PA, Scharnowski F, Jetly R, Frey BN, Hosseiny F, Ros T, Nicholson AA. Contributions of the default mode and central executive networks during posterior cingulate cortex-targeted fMRI neurofeedback in PTSD. Neuroimage Clin. 2025;48:103891. doi: 10.1016/j.nicl.2025.103891. Epub 2025 Oct 22. PMID: 41232478; PMCID: PMC12661201.
  4. Lieberman JM, Lanius RA, Théberge J, Frey BN, Frewen PA, Scharnowski F, Steyrl D, Ros T, Densmore M, Tassinari E, Matic V, Hosseini-Kamkar N, Narikuzhy S, Hosseiny F, Jetly R, Nicholson AA. Study protocol for a multi-session randomized sham-controlled trial of PCC- and amygdala-targeted neurofeedback for the treatment of PTSD. BMC Psychiatry. 2025 Jul 15;25(1):698. doi: 10.1186/s12888-025-07050-5. PMID: 40665286; PMCID: PMC12265235.
  5. Lieberman JM, Rabellino D, Densmore M, Frewen PA, Steyrl D, Scharnowski F, Théberge J, Hosseini-Kamkar N, Neufeld RWJ, Jetly R, Frey BN, Ros T, Lanius RA, Nicholson AA. A tale of two targets: examining the differential effects of posterior cingulate cortex- and amygdala-targeted fMRI-neurofeedback in a PTSD pilot study. Front Neurosci. 2023 Nov 29;17:1229729. doi:10.3389/fnins.2023.1229729. PMID: 38094001; PMCID: PMC10716260.
  6. Shaw, S.B., Terpou, B.A., Densmore, M. et al. Large-scale functional hyperconnectivity patterns in trauma-related dissociation: an rs-fMRI study of PTSD and its dissociative subtype. Nat. Mental Health 1, 711–721 (2023). https://doi.org/10.1038/s44220-023-00115-y
  7. Nicholson AA, Densmore M, Frewen PA, Neufeld RWJ, Théberge J, Jetly R, Lanius RA, Ros T. Homeostatic normalization of alpha brain rhythms within the default-mode network and reduced symptoms in post-traumatic stress disorder following a randomized controlled trial of electroencephalogram neurofeedback. Brain Commun. 2023 Mar 16;5(2):fcad068. doi: 10.1093/braincomms/fcad068. PMID: 37065092; PMCID: PMC10090479.
  8. Lieberman JM, Rabellino D, Densmore M, Frewen PA, Steyrl D, Scharnowski F, Théberge J, Neufeld RWJ, Schmahl C, Jetly R, Narikuzhy S, Lanius RA, Nicholson AA. Posterior cingulate cortex targeted real-time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default-mode network in PTSD. Brain Behav. 2023 Mar;13(3):e2883. doi: 10.1002/brb3.2883. Epub 2023 Feb 15. PMID: 36791212; PMCID: PMC10013955.
  9. Shaw SB, Nicholson AA, Ros T, Harricharan S, Terpou B, Densmore M, Theberge J, Frewen P, Lanius RA. Increased top-down control of emotions during symptom provocation working memory tasks following a RCT of alpha-down neurofeedback in PTSD. Neuroimage Clin. 2023 Jan 3;37:103313. doi:10.1016/j.nicl.2023.103313. Epub ahead of print. PMID: 36669352; PMCID: PMC9868881.
  10. Nicholson AA, Ros T, Densmore M, Frewen PA, Neufeld RWJ, Théberge J, Jetly R, Lanius RA. A randomized, controlled trial of alpha-rhythm EEG neurofeedback in posttraumatic stress disorder: A preliminary investigation showing evidence of decreased PTSD symptoms and restored default mode and salience network connectivity using fMRI. Neuroimage Clin. 2020;28:102490. doi:10.1016/j.nicl.2020.102490. Epub 2020 Nov 5. PMID: 33395981; PMCID: PMC7708928.
  11. Nicholson AA, Rabellino D, Densmore M, Frewen PA, Paret C, Kluetsch R, Schmahl C, Théberge J, Ros T, Neufeld RWJ, McKinnon MC, Reiss JP, Jetly R, Lanius RA. Intrinsic connectivity network dynamics in PTSD during amygdala downregulation using real-time fMRI neurofeedback: A preliminary analysis. Hum Brain Mapp. 2018 Nov;39(11):4258-4275. doi: 10.1002/hbm.24244. Epub 2018 Jul 13. PMID: 30004602; PMCID: PMC8022274.
  12. Nicholson AA, Ros T, Frewen PA, Densmore M, Théberge J, Kluetsch RC, Jetly R, Lanius RA. Alpha oscillation neurofeedback modulates amygdala complex connectivity and arousal in posttraumatic stress disorder. Neuroimage Clin. 2016 Jul 14;12:506-516. doi:10.1016/j.nicl.2016.07.006. PMID: 27672554; PMCID: PMC5030332.
  13. Nicholson AA, Rabellino D, Densmore M, Frewen PA, Paret C, Kluetsch R, Schmahl C, Théberge J, Neufeld RW, McKinnon MC, Reiss J, Jetly R, Lanius RA. The neurobiology of emotion regulation in posttraumatic stress disorder: Amygdala downregulation via real-time fMRI neurofeedback. Hum Brain Mapp. 2017 Jan;38(1):541-560. doi:10.1002/hbm.23402. Epub 2016 Sep 20. PMID: 27647695; PMCID: PMC6866912.
  14. Ros T, Frewen P, Théberge J, Michela A, Kluetsch R, Mueller A, Candrian G, Jetly R, Vuilleumier P, Lanius RA. Neurofeedback Tunes Scale-Free Dynamics in Spontaneous Brain Activity. Cereb Cortex. 2017 Oct 1;27(10):4911-4922. doi:10.1093/cercor/bhw285. PMID: 27620975.
  15. Kluetsch RC, Ros T, Théberge J, Frewen PA, Calhoun VD, Schmahl C, Jetly R, Lanius RA. Plastic modulation of PTSD resting-state networks and subjective wellbeing by EEG neurofeedback. Acta Psychiatr Scand. 2014 Aug;130(2):123-36. doi:10.1111/acps.12229. Epub 2013 Nov 25. PMID: 24266644; PMCID: PMC4442612.
  16. Ros T, Théberge J, Frewen PA, Kluetsch R, Densmore M, Calhoun VD, Lanius RA. Mind over chatter: plastic up-regulation of the fMRI salience network directly after EEG neurofeedback. Neuroimage. 2013 Jan 15;65:324-35. doi:10.1016/j.neuroimage.2012.09.046. Epub 2012 Sep 26. PMID: 23022326; PMCID: PMC5051955.

Development of PET/MRI Hardware Attenuation Correction Approaches

3qchHead Coil_and_Cardiac_Coil

Overview

Brief Description: When developing custom RF coils for simultaneous PET and MRI (or simply using custom hardware within existing RF coils), the need for custom hardware attenuation maps is immediate. Unfortunately, current approaches to obtain these AC maps rely on use of other scanners (like PET/CT) and off-line processing. Objective: Create a simple method using the standard calibration phantoms available on PET/MRI scanner to generate a custom hardware attenuation map online, without use of other scanners. Fund: CFI-LOF(JT), MITACS (JT). Collaborator: Siemens Healthineers, Multi-Magnetic Inc.

Publications

  1. Farag A, Thompson RT, Thiessen JD, Prato FS, Théberge J. Improved PET/MRI accuracy by use of static transmission source in empirically derived hardware attenuation correction. EJNMMI Phys. 2021 Mar 8;8(1):24. doi: 10.1186/s40658-021-00368-5. PMID: 33683464; PMCID: PMC7940463.
  2. Farag A, Thompson RT, Thiessen JD, Biernaski H, Prato FS, Théberge J. Evaluation of 511 keV photon attenuation by a novel 32-channel phased array prospectively designed for cardiovascular hybrid PET/MRI imaging. Eur J Hybrid Imaging. 2020;4(1):7. doi: 10.1186/s41824-020-00076-w. Epub 2020 May 12. PMID: 32626841; PMCID: PMC7324084.
  3. Farag A, Thompson RT, Thiessen JD, Butler J, Prato FS, Théberge J. Assessment of a novel 32-channel phased array for cardiovascular hybrid PET/MRI imaging: MRI performance. Eur J Hybrid Imaging. 2019;3(1):13. doi: 10.1186/s41824-019-0061-7. Epub 2019 Aug 22. PMID: 33283144; PMCID: PMC7717874.

Theses

  1. Farag, Adam H.  (2020) "Improving Hybrid PET/MRI Cardiovascular Imaging with Improved Hardware Design and Attenuation Correction Coefficient", Ph.D. thesis, University of Western Ontario, Medical Biophysics, London, Ontario, Canada[PDF]

Computer-Aided Diagnosis in Unipolar and Bipolar Depression

5_Best_IC_for_Predicting_medication

Overview

Brief Description: Predicting the medication class of response (antidepressant or modd stabilizer) in patients presenting with a first-episode of depressive. Objective: Use resting-state BOLD fMRI scans and independent component analysis to train a machine-learning classification algorithm to improve the physician's ability to prescribe the right medication class upon first examination long before (6-10 years) unipolar or bipolar diagnosis can be confirmed via tradional approaches. Fund: Pfizer Investigator-initiated Grant (EO). Collaborator: Elizabeth Osuch (Psychiatry, FEMAP). My role: Co-applicant.

Publications

  1. Osuch E, Gao S, Wammes M, Théberge J, Willimason P, Neufeld RJ, Du Y, Sui J, Calhoun V. Complexity in mood disorder diagnosis: fMRI connectivity networks predicted medication-class of response in complex patients. Acta Psychiatr Scand. 2018 Nov;138(5):472-482. doi: 10.1111/acps.12945. Epub 2018 Aug 6. PMID: 30084192; PMCID: PMC6204076.
  2. Jie NF, Zhu MH, Ma XY, Osuch EA, Wammes M, Théberge J, Li HD, Zhang Y, Jiang TZ, Sui J, Calhoun VD. Discriminating Bipolar Disorder From Major Depression Based on SVM-FoBa: Efficient Feature Selection With Multimodal Brain Imaging Data. IEEE Trans Auton Ment Dev. 2015 Dec;7(4):320-331. doi: 10.1109/TAMD.2015.2440298. Epub 2015 Oct 26. PMID: 26858825; PMCID: PMC4743532.

Magnetic Resonance Spectroscopy Studies of Schizophrenia

Example of 1.5cc ACC voxel 4 Tesla 1H-MRS spectrum

Overview

Brief Description: Application of high-field magnetic resonance spectroscopy (1H/31P) to schizophrenia research.

Objective: Exploring the progression of abnormalities of glutamatergic and oxidative stress markers in longitudincal studies of patients with first-episode schizophrenia.

Funds: CIHR (LP, JT), CIHR (PW, JT)

Publications

  1. Merritt K, McCutcheon RA, Aleman A, Ashley S, Beck K, Block W, Bloemen OJN, Borgan F, Boules C, Bustillo JR, Capizzano AA, Coughlin JM, David A, de la Fuente-Sandoval C, Demjaha A, Dempster K, Do KQ, Du F, Falkai P, Galińska-Skok B, Gallinat J, Gasparovic C, Ginestet CE, Goto N, Graff-Guerrero A, Ho BC, Howes O, Jauhar S, Jeon P, Kato T, Kaufmann CA, Kegeles LS, Keshavan MS, Kim SY, King B, Kunugi H, Lauriello J, León-Ortiz P, Liemburg E, Mcilwain ME, Modinos G, Mouchlianitis E, Nakamura J, Nenadic I, Öngür D, Ota M, Palaniyappan L, Pantelis C, Patel T, Plitman E, Posporelis S, Purdon SE, Reichenbach JR, Renshaw PF, Reyes-Madrigal F, Russell BR, Sawa A, Schaefer M, Shungu DC, Smesny S, Stanley JA, Stone J, Szulc A, Taylor R, Thakkar KN, Théberge J, Tibbo PG, van Amelsvoort T, Walecki J, Williamson PC, Wood SJ, Xin L, Yamasue H, McGuire P, Egerton A; 1H-MRS in Schizophrenia Investigators. Variability and magnitude of brain glutamate levels in schizophrenia: a meta and mega-analysis. Mol Psychiatry. 2023 May;28(5):2039-2048. doi: 10.1038/s41380-023-01991-7. Epub 2023 Feb 17. PMID: 36806762; PMCID: PMC10575771.
  2. MacKinley M, Ford SD, Jeon P, Théberge J, Palaniyappan L. Central Oxidative Stress and Early Vocational Outcomes in First Episode Psychosis: A 7-Tesla Magnetic Resonance Spectroscopy Study of Glutathione. Schizophr Bull. 2022 Jun 21;48(4):921-930. doi: 10.1093/schbul/sbac012. PMID: 35307736; PMCID: PMC9212125.
  3. Palaniyappan L, Park MTM, Jeon P, Limongi R, Yang K, Sawa A, Théberge J. Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia? Antioxidants (Basel). 2021 Oct 27;10(11):1703. doi: 10.3390/antiox10111703. PMID: 34829575; PMCID: PMC8615159.
  4. Jeon P, Mackinley M, Théberge J, Palaniyappan L. The trajectory of putative astroglial dysfunction in first episode schizophrenia: a longitudinal 7-Tesla MRS study. Sci Rep. 2021 Nov 16;11(1):22333. doi: 10.1038/s41598-021-01773-7. PMID: 34785674; PMCID: PMC8595701.
  5. Jeon P, Limongi R, Ford SD, Mackinley M, Dempster K, Théberge J, Palaniyappan L. Progressive Changes in Glutamate Concentration in Early Stages of Schizophrenia: A Longitudinal 7-Tesla MRS Study. Schizophr Bull Open. 2021 Feb 2;2(1):sgaa072. doi: 10.1093/schizbullopen/sgaa072. PMID: 34746793; PMCID: PMC8561748.
  6. Pan Y, Dempster K, Jeon P, Théberge J, Khan AR, Palaniyappan L. Acute conceptual disorganization in untreated first-episode psychosis: a combined magnetic resonance spectroscopy and diffusion imaging study of the cingulum. J Psychiatry Neurosci. 2021 Apr 27;46(3):E337-E346. doi: 10.1503/jpn.200167. PMID: 33904669; PMCID: PMC8327974.
  7. Park MTM, Jeon P, Khan AR, Dempster K, Chakravarty MM, Lerch JP, MacKinley M, Théberge J, Palaniyappan L. Hippocampal neuroanatomy in first episode psychosis: A putative role for glutamate and serotonin receptors. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Aug 30;110:110297. doi: 10.1016/j.pnpbp.2021.110297. Epub 2021 Mar 7. PMID: 33691200.
  8. Limongi R, Jeon P, Théberge J, Palaniyappan L. Counteracting Effects of Glutathione on the Glutamate-Driven Excitation/Inhibition Imbalance in First-Episode Schizophrenia: A 7T MRS and Dynamic Causal Modeling Study. Antioxidants (Basel). 2021 Jan 8;10(1):75. doi: 10.3390/antiox10010075. PMID: 33430154; PMCID: PMC7828075.
  9. Limongi R, Jeon P, Mackinley M, Das T, Dempster K, Théberge J, Bartha R, Wong D, Palaniyappan L. Glutamate and Dysconnection in the Salience Network: Neurochemical, Effective Connectivity, and Computational Evidence in Schizophrenia. Biol Psychiatry. 2020 Aug 1;88(3):273-281. doi: 10.1016/j.biopsych.2020.01.021. Epub 2020 Feb 6. PMID: 32312577.
  10. Das TK, Dey A, Sabesan P, Javadzadeh A, Théberge J, Radua J, Palaniyappan L. Putative Astroglial Dysfunction in Schizophrenia: A Meta-Analysis of 1H-MRS Studies of Medial Prefrontal Myo-Inositol. Front Psychiatry. 2018 Sep 21;9:438. doi: 10.3389/fpsyt.2018.00438. PMID: 30298023; PMCID: PMC6160540.
  11. Das TK, Javadzadeh A, Dey A, Sabesan P, Théberge J, Radua J, Palaniyappan L. Antioxidant defense in schizophrenia and bipolar disorder: A meta-analysis of MRS studies of anterior cingulate glutathione. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Apr 20;91:94-102. doi: 10.1016/j.pnpbp.2018.08.006. Epub 2018 Aug 17. PMID: 30125624.
  12. Taylor R, Osuch EA, Schaefer B, Rajakumar N, Neufeld RW, Théberge J, Williamson PC. Neurometabolic abnormalities in schizophrenia and depression observed with magnetic resonance spectroscopy at 7 T. BJPsych Open. 2017 Feb 2;3(1):6-11. doi: 10.1192/bjpo.bp.116.003756. PMID: 28243459; PMCID: PMC5288640.
  13. Dempster K, Norman R, Théberge J, Densmore M, Schaefer B, Williamson P. Glutamatergic metabolite correlations with neuropsychological tests in first episode schizophrenia. Psychiatry Res. 2015 Aug 30;233(2):180-5. doi: 10.1016/j.pscychresns.2015.06.003. Epub 2015 Jun 19. PMID: 26163385.
  14. Aoyama N, Théberge J, Drost DJ, Manchanda R, Northcott S, Neufeld RW, Menon RS, Rajakumar N, Pavlosky WF, Densmore M, Schaefer B, Williamson PC. Grey matter and social functioning correlates of glutamatergic metabolite loss in schizophrenia. Br J Psychiatry. 2011 Jun;198(6):448-56. doi: 10.1192/bjp.bp.110.079608. PMID: 21628707.
  15. Théberge J, Williamson KE, Aoyama N, Drost DJ, Manchanda R, Malla AK, Northcott S, Menon RS, Neufeld RW, Rajakumar N, Pavlosky W, Densmore M, Schaefer B, Williamson PC. Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia. Br J Psychiatry. 2007 Oct;191:325-34. doi: 10.1192/bjp.bp.106.033670. PMID: 17906243.
  16. Théberge J, Al-Semaan Y, Jensen JE, Williamson PC, Neufeld RW, Menon RS, Schaefer B, Densmore M, Drost DJ. Comparative study of proton and phosphorus magnetic resonance spectroscopy in schizophrenia at 4 Tesla. Psychiatry Res. 2004 Nov 15;132(1):33-9. doi: 10.1016/j.pscychresns.2004.08.001. PMID: 15546701.
  17. Théberge J, Al-Semaan Y, Drost DJ, Malla AK, Neufeld RW, Bartha R, Manchanda R, Menon R, Densmore M, Schaefer B, Williamson PC. Duration of untreated psychosis vs. N-acetylaspartate and choline in first episode schizophrenia: a 1H magnetic resonance spectroscopy study at 4.0 Tesla. Psychiatry Res. 2004 Jul 30;131(2):107-14. doi: 10.1016/j.pscychresns.2004.04.002. PMID: 15313517.
  18. Théberge J, Al-Semaan Y, Williamson PC, Menon RS, Neufeld RW, Rajakumar N, Schaefer B, Densmore M, Drost DJ. Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS. Am J Psychiatry. 2003 Dec;160(12):2231-3. doi: 10.1176/appi.ajp.160.12.2231. PMID: 14638596.
  19. Théberge J, Bartha R, Drost DJ, Menon RS, Malla A, Takhar J, Neufeld RW, Rogers J, Pavlosky W, Schaefer B, Densmore M, Al-Semaan Y, Williamson PC. Glutamate and glutamine measured with 4.0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers. Am J Psychiatry. 2002 Nov;159(11):1944-6. doi: 10.1176/appi.ajp.159.11.1944. PMID: 12411236.

Book Chapters

  1. Théberge J. (2010) “Assessing in vivo neurodegeneration in schizophrenia using magnetic resonance”, In Ritsner MS (ed). Brain Protection in Schizophrenia, Mood and Anxiety Disorders: From Concept and Mechanisms to Clinical Practice. Springer, pp 67-104. [Link]
  2. Das TS, Dey A, Priyadharshini S, Javadzadeh A, Theberge J, Radua J, Palaniyappan L. (2020). Putative Astroglial Dysfunction in Schizophrenia: A Meta-Analysis of 1H MRS Studies of Medial Prefrontal Myo-Inositol. Fernandes BS, Borgwardt S, Carvalho AF, Steiner J. Back to the Future: On the Road Towards Precision Psychiatry. 1st: 38-47. Published, Frontiers Media SA. [Link]

Functional MRI and resting-state fMRI in psychiatric disorders

Default Mode network Connectivity in Healthy Controls vs Schizophrenia

Overview

Brief Description: Development of data acquisition and data analysis protocols and software for fMRI and resting-state fMRI optimized for applications in psychiatry research.

Objectives: Examining resting-state brain networks and brain connectivity as it realates to clinical vairables. We collaborate with several psychiatrists, psychologists and neuroscientists studying schizophrenia, post-traumatic stress disorder, mood disorders and the concept of "self".

Funds: CIHR, CIMVHR, CFI.

Collaborators: Ruth Lanius, Elisabeth Osuch, Peter Williamson, Paul Frewen, Andrew Nicholson, R. Jim Neufeld. 

Publications

  1. Qi G, Zhang Y, Wang YL, Anjum F, Theberge J, Jiang Y, Khan A, Palaniyappan L. Putative glymphatic function and free water in schizophrenia: A 7T DTI study across psychosis stages. Neuropsychopharmacology. 2026 Jul;51(8):1387-1394. doi: 10.1038/s41386-026-02391-5. Epub 2026 Mar 24. PMID: 41876826; PMCID: PMC13291166.
  2. Andrews K, Lloyd CS, Densmore M, Kearney BE, Harricharan S, McKinnon MC, Théberge J, Jetly R, Lanius RA. 'I am afraid you will see the stain on my soul': Direct gaze neural processing in individuals with PTSD after moral injury recall. Soc Cogn Affect Neurosci. 2023 Oct 26;18(1):nsad053. doi: 10.1093/scan/nsad053. PMID: 37897804; PMCID: PMC10612569.
  3. Zhu X, Kim Y, Ravid O, He X, Suarez-Jimenez B, Zilcha-Mano S, Lazarov A, Lee S, Abdallah CG, Angstadt M, Averill CL, Baird CL, Baugh LA, Blackford JU, Bomyea J, Bruce SE, Bryant RA, Cao Z, Choi K, Cisler J, Cotton AS, Daniels JK, Davenport ND, Davidson RJ, DeBellis MD, Dennis EL, Densmore M, deRoon-Cassini T, Disner SG, Hage WE, Etkin A, Fani N, Fercho KA, Fitzgerald J, Forster GL, Frijling JL, Geuze E, Gonenc A, Gordon EM, Gruber S, Grupe DW, Guenette JP, Haswell CC, Herringa RJ, Herzog J, Hofmann DB, Hosseini B, Hudson AR, Huggins AA, Ipser JC, Jahanshad N, Jia-Richards M, Jovanovic T, Kaufman ML, Kennis M, King A, Kinzel P, Koch SBJ, Koerte IK, Koopowitz SM, Korgaonkar MS, Krystal JH, Lanius R, Larson CL, Lebois LAM, Li G, Liberzon I, Lu GM, Luo Y, Magnotta VA, Manthey A, Maron-Katz A, May G, McLaughlin K, Mueller SC, Nawijn L, Nelson SM, Neufeld RWJ, Nitschke JB, O'Leary EM, Olatunji BO, Olff M, Peverill M, Phan KL, Qi R, Quidé Y, Rektor I, Ressler K, Riha P, Ross M, Rosso IM, Salminen LE, Sambrook K, Schmahl C, Shenton ME, Sheridan M, Shih C, Sicorello M, Sierk A, Simmons AN, Simons RM, Simons JS, Sponheim SR, Stein MB, Stein DJ, Stevens JS, Straube T, Sun D, Théberge J, Thompson PM, Thomopoulos SI, van der Wee NJA, van der Werff SJA, van Erp TGM, van Rooij SJH, van Zuiden M, Varkevisser T, Veltman DJ, Vermeiren RRJM, Walter H, Wang L, Wang X, Weis C, Winternitz S, Xie H, Zhu Y, Wall M, Neria Y, Morey RA. Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium. Neuroimage. 2023 Oct 18;283:120412. doi: 10.1016/j.neuroimage.2023.120412. Epub ahead of print. PMID: 37858907.
  4. Iraji A, Fu Z, Faghiri A, Duda M, Chen J, Rachakonda S, DeRamus T, Kochunov P, Adhikari BM, Belger A, Ford JM, Mathalon DH, Pearlson GD, Potkin SG, Preda A, Turner JA, van Erp TGM, Bustillo JR, Yang K, Ishizuka K, Faria A, Sawa A, Hutchison K, Osuch EA, Theberge J, Abbott C, Mueller BA, Zhi D, Zhuo C, Liu S, Xu Y, Salman M, Liu J, Du Y, Sui J, Adali T, Calhoun VD. Identifying canonical and replicable multi-scale intrinsic connectivity networks in 100k+ resting-state fMRI datasets. Hum Brain Mapp. 2023 Dec 1;44(17):5729-5748. doi: 10.1002/hbm.26472. Epub 2023 Oct 3. PMID: 37787573; PMCID: PMC10619392.
  5. Kearney BE, Terpou BA, Densmore M, Shaw SB, Théberge J, Jetly R, McKinnon MC, Lanius RA. How the body remembers: Examining the default mode and sensorimotor networks during moral injury autobiographical memory retrieval in PTSD. Neuroimage Clin. 2023;38:103426. doi: 10.1016/j.nicl.2023.103426. Epub 2023 Apr 29. PMID: 37207593; PMCID: PMC10206209.
  6. Rabellino D, Thome J, Densmore M, Théberge J, McKinnon MC, Lanius RA. The Vestibulocerebellum and the Shattered Self: a Resting-State Functional Connectivity Study in Posttraumatic Stress Disorder and Its Dissociative Subtype. Cerebellum. 2022 Sep 19. https://doi.org/10.1007/s12311-022-01467-4. Epub ahead of print. PMID: 36121553.
  7. Thome J, Densmore M, Terpou BA, Théberge J, McKinnon MC, Lanius RA. Contrasting Associations Between Heart Rate Variability and Brainstem-Limbic Connectivity in Posttraumatic Stress Disorder and Its Dissociative Subtype: A Pilot Study. Front Behav Neurosci. 2022 May 30;16:862192. doi: 10.3389/fnbeh.2022.862192. PMID: 35706833; PMCID: PMC9190757.
  8. Cakmak JD, Liu L, Poirier SE, Schaefer B, Poolacherla R, Burhan AM, Sabesan P, St Lawrence K, Théberge J, Hicks JW, Finger E, Palaniyappan L, Anazodo UC. The functional and structural associations of aberrant microglial activity in major depressive disorder. J Psychiatry Neurosci. 2022 Jun 2;47(3):E197-E208. https://doi.org/10.1503/jpn.210124. PMID: 35654450; PMCID: PMC9343118.
  9. Terpou BA, Lloyd CS, Densmore M, McKinnon MC, Théberge J, Neufeld RWJ, Jetly R, Lanius RA. Moral wounds run deep: exaggerated midbrain functional network connectivity across the default mode network in posttraumatic stress disorder. J Psychiatry Neurosci. 2022 Feb 17;47(1):E56-E66. https://doi.org/10.1503/jpn.210117. PMID: 35177485; PMCID: PMC8865964.
  10. Lloyd CS, Nicholson AA, Densmore M, Théberge J, Neufeld RWJ, Jetly R, McKinnon MC, Lanius RA. Shame on the brain: Neural correlates of moral injury event recall in posttraumatic stress disorder. Depress Anxiety. 2021 Jun;38(6):596-605. https://doi.org/10.1002/da.23128. Epub 2020 Dec 28. PMID: 33369799.
  11. Terpou BA, Densmore M, Théberge J, Frewen P, McKinnon MC, Nicholson AA, Lanius RA. The hijacked self: Disrupted functional connectivity between the periaqueductal gray and the default mode network in posttraumatic stress disorder using dynamic causal modeling. Neuroimage Clin. 2020;27:102345. doi: 10.1016/j.nicl.2020.102345. Epub 2020 Jul 10. PMID: 32738751; PMCID: PMC7394966.
  12. Nicholson AA, Harricharan S, Densmore M, Neufeld RWJ, Ros T, McKinnon MC, Frewen PA, Théberge J, Jetly R, Pedlar D, Lanius RA. Classifying heterogeneous presentations of PTSD via the default mode, central executive, and salience networks with machine learning. Neuroimage Clin. 2020;27:102262. doi: 10.1016/j.nicl.2020.102262. Epub 2020 Apr 22. PMID: 32446241; PMCID: PMC7240193.
  13. Thome J, Densmore M, Koppe G, Terpou B, Théberge J, McKinnon MC, Lanius RA. Back to the Basics: Resting State Functional Connectivity of the Reticular Activation System in PTSD and its Dissociative Subtype. Chronic Stress (Thousand Oaks). 2019 Sep 27;3:2470547019873663. https://doi.org/10.1177/2470547019873663. PMID: 32440600; PMCID: PMC7219926.
  14. Terpou BA, Densmore M, Théberge J, Thome J, Frewen P, McKinnon MC, Lanius RA. The Threatful Self: Midbrain Functional Connectivity to Cortical Midline and Parietal Regions During Subliminal Trauma-Related Processing in PTSD. Chronic Stress (Thousand Oaks). 2019 Sep 5;3:2470547019871369. doi: 10.1177/2470547019871369. PMID: 32440598; PMCID: PMC7219912.
  15. Harricharan S, Nicholson AA, Thome J, Densmore M, McKinnon MC, Théberge J, Frewen PA, Neufeld RWJ, Lanius RA. PTSD and its dissociative subtype through the lens of the insula: Anterior and posterior insula resting-state functional connectivity and its predictive validity using machine learning. Psychophysiology. 2020 Jan;57(1):e13472. https://doi.org/10.1111/psyp.13472. Epub 2019 Sep 10. PMID: 31502268.
  16. Harricharan S, McKinnon MC, Tursich M, Densmore M, Frewen P, Théberge J, van der Kolk B, Lanius RA. Overlapping frontoparietal networks in response to oculomotion and traumatic autobiographical memory retrieval: implications for eye movement desensitization and reprocessing. Eur J Psychotraumatol. 2019 Mar 25;10(1):1586265. https://doi.org/10.1080/20008198.2019.1586265. PMID: 30949304; PMCID: PMC6442104.
  17. Penner J, Osuch EA, Schaefer B, Théberge J, Neufeld RWJ, Menon RS, Rajakumar N, Williamson PC. Temporoparietal Junction Functional Connectivity in Early Schizophrenia and Major Depressive Disorder. Chronic Stress (Thousand Oaks). 2018 Dec 10;2:2470547018815232. https://doi.org/10.1177/2470547018815232. PMID: 32440588; PMCID: PMC7219936.
  18. Nicholson AA, Densmore M, McKinnon MC, Neufeld RWJ, Frewen PA, Théberge J, Jetly R, Richardson JD, Lanius RA. Machine learning multivariate pattern analysis predicts classification of posttraumatic stress disorder and its dissociative subtype: a multimodal neuroimaging approach. Psychol Med. 2019 Sep;49(12):2049-2059. https://doi.org/10.1017/S0033291718002866. Epub 2018 Oct 11. PMID: 30306886.
  19. Terpou BA, Densmore M, Théberge J, Frewen P, McKinnon MC, Lanius RA. Resting-state pulvinar-posterior parietal decoupling in PTSD and its dissociative subtype. Hum Brain Mapp. 2018 Nov;39(11):4228-4240. doi: 10.1002/hbm.24242. Epub 2018 Aug 9. PMID: 30091811; PMCID: PMC6866494.
  20. Nicholson AA, Rabellino D, Densmore M, Frewen PA, Paret C, Kluetsch R, Schmahl C, Théberge J, Ros T, Neufeld RWJ, McKinnon MC, Reiss JP, Jetly R, Lanius RA. Intrinsic connectivity network dynamics in PTSD during amygdala downregulation using real-time fMRI neurofeedback: A preliminary analysis. Hum Brain Mapp. 2018 Nov;39(11):4258-4275. https://doi.org/10.1002/hbm.24244. Epub 2018 Jul 13. PMID: 30004602; PMCID: PMC8022274.
  21. Rabellino D, Densmore M, Théberge J, McKinnon MC, Lanius RA. The cerebellum after trauma: Resting-state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype. Hum Brain Mapp. 2018 Aug;39(8):3354-3374. https://doi.org/10.1002/hbm.24081. Epub 2018 Apr 17. PMID: 29667267; PMCID: PMC6866303.
  22. Penner J, Osuch EA, Schaefer B, Théberge J, Neufeld RWJ, Menon RS, Rajakumar N, Bourne JA, Williamson PC. Higher order thalamic nuclei resting network connectivity in early schizophrenia and major depressive disorder. Psychiatry Res Neuroimaging. 2018 Feb 28;272:7-16. https://doi.org/10.1016/j.pscychresns.2017.12.002. Epub 2017 Dec 8. PMID: 29247717.
  23. Olivé I, Densmore M, Harricharan S, Théberge J, McKinnon MC, Lanius R. Superior colliculus resting state networks in post-traumatic stress disorder and its dissociative subtype. Hum Brain Mapp. 2018 Jan;39(1):563-574. doi: 10.1002/hbm.23865. Epub 2017 Nov 13. PMID: 29134717; PMCID: PMC6866590.
  24. Harricharan S, Nicholson AA, Densmore M, Théberge J, McKinnon MC, Neufeld RWJ, Lanius RA. Sensory overload and imbalance: Resting-state vestibular connectivity in PTSD and its dissociative subtype. Neuropsychologia. 2017 Nov;106:169-178. https://doi.org/10.1016/j.neuropsychologia.2017.09.010. Epub 2017 Sep 11. PMID: 28911803.
  25. Nicholson AA, Friston KJ, Zeidman P, Harricharan S, McKinnon MC, Densmore M, Neufeld RWJ, Théberge J, Corrigan F, Jetly R, Spiegel D, Lanius RA. Dynamic causal modeling in PTSD and its dissociative subtype: Bottom-up versus top-down processing within fear and emotion regulation circuitry. Hum Brain Mapp. 2017 Nov;38(11):5551-5561. https://doi.org/10.1002/hbm.23748. Epub 2017 Aug 24. PMID: 28836726; PMCID: PMC6866710.
  26. Rabellino D, D'Andrea W, Siegle G, Frewen PA, Minshew R, Densmore M, Neufeld RW, Théberge J, McKinnon MC, Lanius RA. Neural correlates of heart rate variability in PTSD during sub- and supraliminal processing of trauma-related cues. Hum Brain Mapp. 2017 Oct;38(10):4898-4907. https://doi.org/10.1002/hbm.23702. Epub 2017 Jul 17. PMID: 28714594; PMCID: PMC6867110.
  27. Harricharan S, Rabellino D, Frewen PA, Densmore M, Théberge J, McKinnon MC, Schore AN, Lanius RA. fMRI functional connectivity of the periaqueductal gray in PTSD and its dissociative subtype. Brain Behav. 2016 Sep 20;6(12):e00579. doi: 10.1002/brb3.579. PMID: 28032002; PMCID: PMC5167004.
  28. Taylor R, Théberge J, Williamson PC, Densmore M, Neufeld RW. ACC Neuro-over-Connectivity Is Associated with Mathematically Modeled Additional Encoding Operations of Schizophrenia Stroop-Task Performance. Front Psychol. 2016 Sep 16;7:1295. https://doi.org/10.3389/fpsyg.2016.01295. PMID: 27695425; PMCID: PMC5025455.
  29. Thome J, Densmore M, Frewen PA, McKinnon MC, Théberge J, Nicholson AA, Koenig J, Thayer JF, Lanius RA. Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder. Hum Brain Mapp. 2017 Jan;38(1):27-40. https://doi.org/10.1002/hbm.23340. Epub 2016 Sep 20. PMID: 27647521; PMCID: PMC6866719.
  30. Rabellino D, Densmore M, Frewen PA, Théberge J, McKinnon MC, Lanius RA. Aberrant Functional Connectivity of the Amygdala Complexes in PTSD during Conscious and Subconscious Processing of Trauma-Related Stimuli. PLoS One. 2016 Sep 15;11(9):e0163097. https://doi.org/10.1371/journal.pone.0163097. PMID: 27631496; PMCID: PMC5025207.
  31. Penner J, Ford KA, Taylor R, Schaefer B, Théberge J, Neufeld RW, Osuch EA, Menon RS, Rajakumar N, Allman JM, Williamson PC. Medial Prefrontal and Anterior Insular Connectivity in Early Schizophrenia and Major Depressive Disorder: A Resting Functional MRI Evaluation of Large-Scale Brain Network Models. Front Hum Neurosci. 2016 Mar 30;10:132. https://doi.org/10.3389/fnhum.2016.00132. PMID: 27064387; PMCID: PMC4811885.
  32. Nicholson AA, Sapru I, Densmore M, Frewen PA, Neufeld RW, Théberge J, McKinnon MC, Lanius RA. Unique insula subregion resting-state functional connectivity with amygdala complexes in posttraumatic stress disorder and its dissociative subtype. Psychiatry Res Neuroimaging. 2016 Apr 30;250:61-72. doi: 10.1016/j.pscychresns.2016.02.002. Epub 2016 Apr 1. PMID: 27042977.
  33. Rabellino D, Densmore M, Frewen PA, Théberge J, Lanius RA. The innate alarm circuit in post-traumatic stress disorder: Conscious and subconscious processing of fear- and trauma-related cues. Psychiatry Res Neuroimaging. 2016 Feb 28;248:142-50. https://doi.org/10.1016/j.pscychresns.2015.12.005. Epub 2015 Dec 23. PMID: 26749205.
  34. Rabellino D, Tursich M, Frewen PA, Daniels JK, Densmore M, Théberge J, Lanius RA. Intrinsic Connectivity Networks in post-traumatic stress disorder during sub- and supraliminal processing of threat-related stimuli. Acta Psychiatr Scand. 2015 Nov;132(5):365-78. https://doi.org/10.1111/acps.12418. Epub 2015 Apr 11. PMID: 25865357.
  35. Steuwe C, Daniels JK, Frewen PA, Densmore M, Theberge J, Lanius RA. Effect of direct eye contact in women with PTSD related to interpersonal trauma: Psychophysiological interaction analysis of connectivity of an innate alarm system. Psychiatry Res. 2015 May 30;232(2):162-7. doi: 10.1016/j.pscychresns.2015.02.010. Epub 2015 Mar 9. PMID: 25862529.
  36. Nicholson AA, Densmore M, Frewen PA, Théberge J, Neufeld RW, McKinnon MC, Lanius RA. The Dissociative Subtype of Posttraumatic Stress Disorder: Unique Resting-State Functional Connectivity of Basolateral and Centromedial Amygdala Complexes. Neuropsychopharmacology. 2015 Sep;40(10):2317-26. doi: 10.1038/npp.2015.79. Epub 2015 Mar 19. PMID: 25790021; PMCID: PMC4538346.
  37. Ford KA, Théberge J, Neufeld RJ, Williamson PC, Osuch EA. Correlation of brain default mode network activation with bipolarity index in youth with mood disorders. J Affect Disord. 2013 Sep 25;150(3):1174-8. doi: 10.1016/j.jad.2013.05.088. Epub 2013 Jun 24. PMID: 23806586.
  38. Frewen PA, Lundberg E, Brimson-Théberge M, Théberge J. Neuroimaging self-esteem: a fMRI study of individual differences in women. Soc Cogn Affect Neurosci. 2013 Jun;8(5):546-55. https://doi.org/10.1093/scan/nss032. Epub 2012 Mar 7. PMID: 22403154; PMCID: PMC3682439.
  39. Bluhm R, Williamson P, Lanius R, Théberge J, Densmore M, Bartha R, Neufeld R, Osuch E. Resting state default-mode network connectivity in early depression using a seed region-of-interest analysis: decreased connectivity with caudate nucleus. Psychiatry Clin Neurosci. 2009 Dec;63(6):754-61. doi: 10.1111/j.1440-1819.2009.02030.x. PMID: 20021629.
  40. Bluhm RL, Miller J, Lanius RA, Osuch EA, Boksman K, Neufeld RW, Théberge J, Schaefer B, Williamson PC. Retrosplenial cortex connectivity in schizophrenia. Psychiatry Res. 2009 Oct 30;174(1):17-23. doi: 10.1016/j.pscychresns.2009.03.010. Epub 2009 Sep 23. PMID: 19783410.
  41. Osuch EA, Bluhm RL, Williamson PC, Théberge J, Densmore M, Neufeld RW. Brain activation to favorite music in healthy controls and depressed patients. Neuroreport. 2009 Aug 26;20(13):1204-8. https://doi.org/10.1097/WNR.0b013e32832f4da3. PMID: 19617860.
  42. Bluhm RL, Williamson PC, Osuch EA, Frewen PA, Stevens TK, Boksman K, Neufeld RW, Théberge J, Lanius RA. Alterations in default network connectivity in posttraumatic stress disorder related to early-life trauma. J Psychiatry Neurosci. 2009 May;34(3):187-94. PMID: 19448848; PMCID: PMC2674971.
  43. Lanius RA, Bluhm RL, Coupland NJ, Hegadoren KM, Rowe B, Théberge J, Neufeld RW, Williamson PC, Brimson M. Default mode network connectivity as a predictor of post-traumatic stress disorder symptom severity in acutely traumatized subjects. Acta Psychiatr Scand. 2010 Jan;121(1):33-40. doi: 10.1111/j.1600-0447.2009.01391.x. Epub 2009 May 7. PMID: 19426163.
  44. Bluhm RL, Osuch EA, Lanius RA, Boksman K, Neufeld RW, Théberge J, Williamson P. Default mode network connectivity: effects of age, sex, and analytic approach. Neuroreport. 2008 May 28;19(8):887-91. doi: 10.1097/WNR.0b013e328300ebbf. PMID: 18463507.
  45. Bluhm RL, Miller J, Lanius RA, Osuch EA, Boksman K, Neufeld RW, Théberge J, Schaefer B, Williamson P. Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default network. Schizophr Bull. 2007 Jul;33(4):1004-12. https://doi.org/10.1093/schbul/sbm052. Epub 2007 Jun 7. PMID: 17556752; PMCID: PMC2632312.
  46. Boksman K, Théberge J, Williamson P, Drost DJ, Malla A, Densmore M, Takhar J, Pavlosky W, Menon RS, Neufeld RW. A 4.0-T fMRI study of brain connectivity during word fluency in first-episode schizophrenia. Schizophr Res. 2005 Jun 15;75(2-3):247-63. https://doi.org/10.1016/j.schres.2004.09.025. Epub 2004 Nov 11. PMID: 15885517.

Functional and metabolic effects of substances use in psychiatric disorders

Difference in Default Mode Network brain connectivity between individuals who have used marijuana before 17 years old and those who started later

Overview

Brief Description: Determine the impact of substance use (marijuana, nicotine) on brain connectivity in youth with mood disorders.

Objectives: Determining the interplay between substance use and the development of mood disorders. Explore the effect of age of first exposure on brain functional connectivity using resting state fMRI and on brain metabolism using magnetic resonance spectroscopy.

Fund: OMHF (EO), Western University (SL)

Collaborators: Elizabeth Osuch (psychiatry, FEMAP), Steven Laviolette ( Anatomy & Cell Biology, Western University), Jibran Khokar (Anatomy & Cell Biology, Western University).

Publications

  1. Nichols ES, Penner J, Ford KA, Wammes M, Neufeld RWJ, Mitchell DGV, Greening SG, Théberge J, Williamson PC, Osuch EA. Emotion regulation in emerging adults with major depressive disorder and frequent cannabis use. Neuroimage Clin. 2021;30:102575. doi: 10.1016/j.nicl.2021.102575. Epub 2021 Jan 26. PMID: 33588323; PMCID: PMC7895841.
  2. Osuch EA, Manning K, Hegele RA, Théberge J, Neufeld R, Mitchell D, Williamson P, Gardner RC. Depression, marijuana use and early-onset marijuana use conferred unique effects on neural connectivity and cognition. Acta Psychiatr Scand. 2016 Nov;134(5):399-409. doi: 10.1111/acps.12629. Epub 2016 Aug 27. PMID: 27565994.
  3. 3: Ford KA, Wammes M, Neufeld RW, Mitchell D, Théberge J, Williamson P, Osuch EA. Unique functional abnormalities in youth with combined marijuana use and depression: an FMRI study. Front Psychiatry. 2014 Sep 26;5:130. doi: 10.3389/fpsyt.2014.00130. PMID: 25309462; PMCID: PMC4176032.

Media Stories

  1. 2024 March 26th - La presse Canadienne - [Link] 
  2. 2024 March 25th - Radio Canada - Rouyn-Noranda. Audio: [French] 
  3. 2024 March 20th - Sept-Ile. Audio [French] 
  4. 2024 Feb - Schulich School of Medicine and Dentristry [Link] 

Brain Imaging in Other Non-psychiatric Disorders

fMRI time-courses during insulin clamp

Overview

Brief Description: The imaging expertise developped to measure subtle changes seen in psychiatric disorders can be applied to other non-psychiatric disorders.

Objectives: For example, we have applied perfusion MRI methods to studies of Diabetes. We have used MRI and MRS in studying the effect of hemodialysis on the brain. We have studied the impact of thrombotic disoders on white matter of the brain.

Fund: NIH (DS),  HSF(CM), PSI Foundation (SH)

Collaborators: Donald Simonson (Joslin Diabetes Center, Boston, MA, USA), Nicolas Bolo (Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, USA); Christopher McIntyre (Western University & Lilibeth Caberto Kidney Clinical Research Unit), Udunna Anazodo (McGill University); Shi-Han Susan Huang (Nephrology, Western University).

Publications

  1. Hannan F, Thiessen JD, Patriquin CJ, Pavenski K, Tristao L, Lee TY, Mendes D, Théberge J, Mandzia JL, Al-Jaishi M, Gallo KL, Huang SS. Neurological Impact of Caplacizumab in Refractory iTTP Survivors: A Comparative Study of Blood-Brain-Barrier Integrity and Cognitive Outcomes. Arterioscler Thromb Vasc Biol. 2026 Jul;46(7):e324382. doi: 10.1161/ATVBAHA.126.324382. Epub 2026 May 7. PMID: 42093640.
  2. Hannan F, Thiessen JD, Patriquin CJ, Pavenski K, Tristao L, Lee TY, Mendes D, Poirier S, Théberge J, Mandzia J, Al-Jaishi M, Gallo K, Huang SS. Endothelial injury to cognitive decline: a 12-month follow-up using computed tomography perfusion and diffusion magnetic resonance imaging in immune-mediated thrombotic thrombocytopenic purpura. J Thromb Haemost. 2026 May;24(5):1700-1712. doi: 10.1016/j.jtha.2025.12.021. Epub 2026 Jan 19. PMID: 41564973.
  3. Kosalka PK, Hannan F, Hamilton J, Patriquin CJ, Pavenski K, Jurkiewicz MT, Tristao L, Owen AM, Deoni SCL, Théberge J, Mandzia J, Thiessen JD, Garland JS, McGrath SB, Huang SS. Characterizing the association between complement-mediated TMA and cognitive dysfunction using MRI and neurocognitive assessment. Blood Vessel Thromb Hemost. 2024 Jun 24;1(3):100016. doi: 10.1016/j.bvth.2024.100016. PMID: 40766815; PMCID: PMC12320465.
  4. Hannan F, Hamilton J, Patriquin CJ, Pavenski K, Jurkiewicz MT, Tristao L, Owen AM, Kosalka PK, Deoni SCL, Théberge J, Mandzia J, Huang SHS, Thiessen JD. Cognitive decline in thrombotic thrombocytopenic purpura survivors: The role of white matter health as assessed by MRI. Br J Haematol. 2023 Dec 11. doi: 10.1111/bjh.19246. Epub ahead of print. PMID: 38083818.
  5. Kosalka PK, Hannan F, Hamilton J, Patriquin CJ, Pavenski K, Jurkiewicz MT, Tristao L, Owen AM, Deoni SCL, Théberge J, Mandzia J, Thiessen JD, Garland JS, McGrath SB, Huang SHS. Characterizing the association between complement-mediated TMA and cognitive dysfunction using MRI and neurocognitive assessment. Blood Vessells, Thrombosis & Hemostasis 2024 Sep 23;1(3):100016. doi: 10.1016/j.bvth.2024.100016
  6. Bolo NR, Musen G, Jacobson AM, Weinger K, McCartney RL, Flores V, Renshaw PF, Simonson DC. Brain activation during working memory is altered in patients with type 1 diabetes during hypoglycemia. Diabetes. 2011 Dec;60(12):3256-64. doi: 10.2337/db11-0506. Epub 2011 Oct 7. PMID: 21984582; PMCID: PMC3219930.
  7. Anazodo UC, Wong DY, Théberge J, Dacey M, Gomes J, Penny JD, van Ginkel M, Poirier SE, McIntyre CW. Hemodialysis-Related Acute Brain Injury Demonstrated by Application of Intradialytic Magnetic Resonance Imaging and Spectroscopy. J Am Soc Nephrol. 2023 Jun 1;34(6):1090-1104. doi: 10.1681/ASN.0000000000000105. Epub 2023 Mar 9. PMID: 36890644; PMCID: PMC10278857.

Abstracts

  1. DONALD C. SIMONSON, NICOLAS R. BOLO, JEAN THEBERGE, GAIL MUSEN, ALAN M. JACOBSON; 49-OR: Changes in Regional Cerebral Blood Flow during Hypoglycemia in T1DM. Diabetes 1 June 2021; 70 (Supplement_1): 49–OR. https://doi.org/10.2337/db21-49-

Collaborative Multi-Site Studies

Multi-Site Study Pictogram

Overview

This research theme regroups studies that are conducted as part of a large group of investigators across several institutions.

Collaborators: The ENIGMA Consortium

Publications

  1. Steele N, Hussain A, Sun D, Baird CL, Russell C, Jahanshad N, Salminen LE, Olff M, Frijling JL, Veltman DJ, Koch SBJ, Nawijn L, van Zuiden M, Wang L, Zhu Y, Li G, Stein DJ, Ipser J, Koopowitz S, Neria Y, Zhu X, Ravid O, Zilcha-Mano S, Lazarov A, Suarez-Jimenez B, Huggins AA, Stevens J, Ressler K, Jovanovic T, van Rooij SJH, Fani N, Dennis EL, Tate DF, Cifu DX, Walker WC, Wilde EA, Rektor I, Říha P, Kaufman ML, Lebois LAM, Baker JT, King A, Liberzon I, Angstadt M, Davenport ND, Disner SG, Sponheim SR, Straube T, Hofmann D, Lu GM, Qi R, Etkin A, Maron-Katz A, Wang X, Kunch A, Xie H, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce SE, Cisler J, Ross M, Herringa R, Grupe DW, Nitschke JB, Davidson RJ, Larson C, deRoon-Cassini TA, Tomas CW, Fitzgerald JM, Feola B, Blackford JU, Olatunji BO, May G, Nelson SM, Gordon EM, Abdallah CG, Lanius R, Densmore M, Théberge J, Neufeld RWJ, Thompson PM, Morey RA. Disrupted intrathalamic and thalamocortical structural covariance networks in posttraumatic stress disorder. Netw Neurosci. 2026 Mar 20;10(1):244-266. doi: 10.1162/NETN.a.535. PMID: 41878614; PMCID: PMC13008379.
  2. Steele N, Hussain A, Sun D, Russell C, Huggins AA, Davenport ND, Disner SG, Sponheim SR, Straube T, Hofmann D, Lissek S, Berg H, Grupe DW, Nitschke JB, Davidson RJ, Lanius R, Densmore M, Théberge J, Neufeld RWJ, Thomopoulos SI, Thompson PM, Morey RA. Disrupted thalamocortical functional connectivity and canonical resting-state network integration in posttraumatic stress disorder. Neuroimage Clin. 2026;49:103927. doi: 10.1016/j.nicl.2025.103927. Epub 2025 Dec 12. PMID: 41421150; PMCID: PMC12775856.
  3. Hinojosa CA, Sun D, Russell C, Baird CL, Hussain A, Sendi M, Jahanshad N, Salminen LE, Olff M, Frijling JL, Veltman DJ, Koch SBJ, Nawijn L, van Zuiden M, Wang L, Zhu Y, Li G, Stein DJ, Ipser J, Koopowitz SM, Neria Y, Zhu X, Ravid O, Zilcha-Mano S, Lazarov A, Suarez-Jimenez B, Huggins AA, Ressler K, Jovanovic T, Fani N, Mueller SC, Hudson AR, Daniels JK, Sierk A, Manthey A, Walter H, van der Wee NJA, van der Werff SJA, Vermeiren RRJM, Rektor I, Říha P, Kaufman ML, Lebois LAM, Baker JT, King A, Liberzon I, Angstadt M, Davenport ND, Disner SG, Sponheim SR, Straube T, Hofmann D, Lu GM, Qi R, Wang X, Kunch A, Xie H, Quidé Y, El-Hage W, Lissek S, Berg H, Cisler J, Ross M, Herringa RJ, Grupe DW, Nitschke JB, Davidson RJ, Larson CL, deRoon-Cassini TA, Tomas CW, Fitzgerald JM, Feola B, Urbano-Blackford J, Olatunji BO, May G, Nelson SM, Gordon EM, Abdallah CG, Lanius R, Densmore M, Théberge J, Neufeld RWJ, Baugh LA, Simons RM, Simons JS, Magnotta VA, Fercho KA, Elman J, Panizzon M, Franz C, Lyons MJ, Kremen W, McLaughin KA, Peverill M, Sambrook K, Thompson PM, Stevens JS, Morey RA, van Rooij SJH. Resting-State Functional Connectivity of the Amygdala and Hippocampus in PTSD: Results From the PGC-ENIGMA PTSD Working Group. Am J Psychiatry. 2026 May 1;183(5):333-342. doi: 10.1176/appi.ajp.20250062. Epub 2026 Apr 2. PMID: 41922983.
  4. Wang HR, Liu ZQ, Pozzi E, Hussain A, Sigar P, Abdallah C, Alexander N, Baker J, Bauer J, Blackford JU, Cisler J, Connolly CG, Cotton A, Daniels J, Dannlowski U, Densmore M, deRoon-Cassini T, Dima D, Du Plessis S, Etkin A, Fani N, Fisch L, Fitzgerald J, Frodl T, Fu CHY, Gonul AS, Gordon EM, Gotlib IH, Goya-Maldonado R, Groenewold NA, Grotegerd D, Hahn T, Hamilton JP, Han LKM, Harpaz-Rotem I, Haswell CC, Herringa R, Herzog J, Ipser J, Jahanshad N, Jovanovic T, Kaufman M, Kircher T, Konowski M, Koopowitz SM, Krug A, Krystal J, Lanius R, Larson C, Lazarov A, Lebois L, Leehr E, Levy I, Li M, Manthey A, Maron-Katz A, McIntosh AM, McLaughlin KA, Meinert S, Mwangi B, Nelson SM, Nenadić I, Neria Y, Neufeld R, Ojha A, Olatunji BO, Olson EA, Opel N, Peverill M, Ressler K, Ross M, Rosso I, Sacchet MD, Sambrook K, Schmahl C, Seedat S, Shenton ME, Sicorello M, Sierk A, Soares JC, Stein DJ, Stein F, Stein MB, Suarez-Jimenez B, Théberge J, Thomopoulos SI, Tomas C, Usemann P, van den Heuvel LL, van Rooij SJH, Walter H, Walter M, Wang X, Whalley HC, Winter NR, Wu MJ, Xie H, Yang TT, Zhu X, Zilcha-Mano S, Zunta-Soares GB, Frangou S, Thompson PM, Salminen L, Sun D, Morey R, Stevens JS, Schmaal L, Ho TC. Childhood Maltreatment and Deviations From Normative Brain Structure: A Mega-Analysis of 3711 Individuals From the ENIGMA Major Depressive Disorder and ENIGMA Posttraumatic Stress Disorder Working Groups. Biol Psychiatry. 2026 Mar 5:S0006-3223(26)00093-4. doi: 10.1016/j.biopsych.2026.02.016. Epub ahead of print. PMID: 41791639.
  5. Hussain A, Baird CL, Huggins AA, Russell CC, Sun D, Rangel-Jimenez L, Abdallah CG, Angstadt M, May G, Berg H, Blackford JU, Cisler J, Daniels JK, Davenport ND, Davidson RJ, Densmore M, Disner SG, El-Hage W, Etkin A, Fani N, Frijling JL, Gordon EM, Grupe DW, Herringa RA, Herzog JI, Hofmann D, Hudson AR, Jovanovic T, King A, Koch SBJ, Lanius RA, Lazarov A, Li G, Liberzon I, Lissek S, Lu G, Manthey A, Maron-Katz A, McLaughlin KA, Mueller SC, Nawijn L, Nelson SM, Neria Y, Neufeld RWJ, Nitschke JB, Olatunji BO, Olff M, Peverill M, Qi R, Quidé Y, Ravid O, Rektor I, Ressler KJ, Říha P, Ross M, Sambrook K, Schmahl C, Sierk A, Sponheim SR, Stevens JS, Straube T, Suarez-Jimenez B, Théberge J, van der Wee NJA, van der Werff SJA, van Rooij SJH, van Zuiden M, Veltman DJ, Vermeiren RRJM, Walter H, Wang L, Zhu X, Zhu Y, Zilcha-Mano S, Jahanshad N, Thompson PM, Morey RA. Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study. Biol Psychiatry Glob Open Sci. 2025 Dec 18;6(2):100679. doi: 10.1016/j.bpsgos.2025.100679. PMID: 41685071; PMCID: PMC12892079.
  6. Steele N, Hussain A, Baird CL, Haswell CC, Sun D, Rangel-Jimenez L, Abdallah CG, Angstadt M, May G, Berg H, Blackford JU, Cisler JM, Daniels JK, Davenport ND, Davidson RJ, Densmore M, Disner SG, El-Hage W, Etkin A, Fani N, Frijling JL, Gordon EM, Grupe DW, Herringa RJ, Hudson AR, Jahanshad N, Jovanovic T, King A, Koch SBJ, Lanius R, Lazarov A, Li G, Liberzon I, Lissek S, Lu G, Manthey A, Maron-Katz A, Nawijn L, Nelson SM, Neria Y, Neufeld RWJ, Nitschke JB, Olatunji BO, Olff M, Peverill M, Quidé Y, Ravid O, Rakesh G, Ressler K, Ross M, Sambrook K, Sierk A, Sponheim SR, Stevens J, Suarez-Jimenez B, Théberge J, van Rooij SJH, van Zuiden M, Veltman DJ, Vermeiren RRJM, Walter H, Wang L, Zhu X, Zhu Y, Zilcha-Mano S, Larson C, deRoon-Cassini TA, Tomas CW, Fitzgerald JM, Cotton AS, O'Leary EN, Xie H, Wang X, Dennis EL, Tate DF, Cifu DX, Walker WC, Wilde EA, Thompson PM, Morey RA. Volumetric Differences of Thalamic Nuclei Are Associated With Posttrauma Psychopathology. Biol Psychiatry Cogn Neurosci Neuroimaging. 2026 Jun;11(6):657-667. doi: 10.1016/j.bpsc.2025.10.016. Epub 2025 Oct 31. PMID: 41177253.
  7. Harnett NG, Joshi S, Kumar P, Russell C, Dillon DG, Baker JT, Pizzagalli DA, Kaufman ML, Nickerson LD, Jahanshad N, Salminen LE, Thomopoulos SI, Frijling JL, Veltman DJ, Koch SBJ, Nawijn L, van Zuiden M, Zhu Y, Li G, Ipser J, Zhu X, Ravid O, Zilcha-Mano S, Lazarov A, Suarez-Jimenez B, Sun D, Hussain A, Huggins AA, Jovanovic T, van Rooij SJH, Fani N, Hudson AR, Sierk A, Manthey A, Walter H, van der Wee NJA, van der Werff SJA, Vermeiren RRJM, Říha P, Lebois LAM, Rosso IM, Olson EA, Liberzon I, Angstadt M, Disner SG, Sponheim SR, Koopowitz SM, Hofmann D, Qi R, Maron-Katz A, Kunch A, Xie H, El-Hage W, Berg H, Bruce SE, McLaughlin KA, Peverill M, Sambrook K, Ross M, Herringa RJ, Nitschke JB, Davidson RJ, deRoon-Cassini TA, Tomas CW, Fitzgerald JM, Blackford JU, Olatunji BO, Nelson SM, Gordon EM, Densmore M, Théberge J, Neufeld RWJ, Olff M, Wang L, Stein DJ, Neria Y, Stevens JS, Mueller SC, Daniels JK, Rektor I, King A, Davenport ND, Straube T, Lu G, Etkin A, Wang X, Quidé Y, Lissek S, Cisler J, Grupe DW, Larson C, Feola B, May G, Abdallah CG, Lanius R, Thompson PM, Morey RA, Ressler KJ. Structural Covariance of Early Visual Cortex Is Negatively Associated With Posttraumatic Stress Disorder Symptoms: A Mega-Analysis From the ENIGMA PTSD Working Group. Biol Psychiatry Cogn Neurosci Neuroimaging. 2026 Jan;11(1):48-57. doi: 10.1016/j.bpsc.2025.07.005. Epub 2025 Jul 23. PMID: 40712699; PMCID: PMC12404044.
  8. Steele N, Huggins AA, Morey RA, Hussain A, Russell C, Suarez-Jimenez B, Pozzi E, Jameei H, Schmaal L, Veer IM, Waller L, Jahanshad N, Thomopoulos SI, Salminen LE, Olff M, Frijling JL, Veltman DJ, Koch SBJ, Nawijn L, van Zuiden M, Wang L, Zhu Y, Li G, Stein DJ, Ipser J, Neria Y, Zhu X, Ravid O, Zilcha-Mano S, Lazarov A, Stevens JS, Ressler K, Jovanovic T, van Rooij SJH, Fani N, Mueller SC, Hudson AR, Daniels JK, Sierk A, Manthey A, Walter H, van der Wee NJA, van der Werff SJA, Vermeiren RRJM, Schmahl C, Herzog JI, Rektor I, Říha P, Kaufman ML, Lebois LAM, Baker JT, Rosso IM, Olson EA, King A, Liberzon I, Angstadt M, Davenport ND, Disner SG, Sponheim SR, Straube T, Hofmann D, Lu G, Qi R, Wang X, Kunch A, Xie H, Quidé Y, El-Hage W, Lissek S, Berg H, Bruce SE, Cisler J, Ross M, Herringa RJ, Grupe DW, Nitschke JB, Davidson RJ, Larson C, deRoon-Cassini TA, Tomas CW, Fitzgerald JM, Elman J, Panizzon M, Franz CE, Lyons MJ, Kremen WS, Feola B, Blackford JU, Olatunji BO, May G, Nelson SM, Gordon EM, Abdallah CG, Lanius R, Densmore M, Théberge J, Neufeld RWJ, Thompson PM, Sun D. Image-based meta- and mega-analysis (IBMMA): A unified framework for large-scale, multi-site, neuroimaging data analysis. Neuroimage. 2025 Nov 15;322:121554. doi: 10.1016/j.neuroimage.2025.121554. Epub 2025 Oct 23. PMID: 41138791; PMCID: PMC12875043.
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