Ting-Yim Lee

T.-Y. Lee

Credentials:

PhD, FCCPM, FCOMP

Affiliations

  • Director, PET/CT Research, Lawson Health Research Institute
  • Director, Stroke Imaging Research, Department of Medical Imaging, University of Western Ontario
  • Imaging Scientist, Lawson Health Research Institute
  • Professor, Departments of Medical Biophysics and Medical Imaging, University of Western Ontario
  • Scientist, Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario
  • Medical Physicist, Department of Radiology, St. Joseph's Health Care, London

Biography

My research program focuses on the use of imaging to study (patho)physiological processes in diseases. My lab has pioneered a method of using x-ray dye and CT scanning to measure blood flow and related parameters in various tissues including the brain, tumours and the heart. The method has found applications in stroke for selection of patients for thrombolytic treatment, in cancer for the monitoring of anti-angiogenesis therapy and in heart attack for identifying patients who would benefit from revascularization. The software implementation of the method has been licensed to GE Healthcare and is distributed worldwide for use in their CT scanners. My current research is addressing the following questions: • Can measurement of blood flow and blood-brain barrier permeability identify ischemic penumbra (viable tissue) from infarction (dead tissue) and assess risk of hemorrhagic transformation (bleeding) in acute stroke patients? • Can measurements of blood flow reflect the efficacy of anti-angiogenesis treatment of cancer? • Is the blood-brain barrier compromised in vascular cognitive impairment and Alzheimer disease? • Can new image reconstruction and analysis algorithms reduce the radiation dose from CT blood flow studies to levels that allow repeated measurements in the same patient to track the progression of disease and responses to treatment?

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