Cyclotron & PET Radiochemistry

Description
 

CyclotronCyclotron

The Nordal Cyclotron & PET Radiochemistry Facility is used to produce positron-emitting radiopharmaceuticals (PERs). The half-life of the radioactive isotopes incorporated into the PERs is short, which necessitates generating them with a cyclotron in close proximity to the clinic. The cyclotron-produced PERs are then injected into patients for a positron emission tomography (PET) scan. The Lawson Cyclotron facility produces short-lived PERs for the St. Joseph’s Health Care, London PET scanners, and will eventually be the centre of a regional distribution network for PERs.

In addition, the Lawson Cyclotron facility is involved in a multi-centre study to develop methods to manufacture Technetium radioisotopes (e.g. Tc-99m) directly from a cyclotron and formulate and assess the suitability of these radioisotopes for human use.

 

Cyclotron (Inner View)Cyclotron (Inner View)FastLabFastLabTracerLabTracerLab

 

Equipment Capabilities

  • GE PETtrace 880 cyclotron
  • Comecer hotcells (7) with 11 chambers
  • GE Fastlab synthesizer (2)
  • GE Tracer labs (3)
  • TRIUMF high power solid target station
  • Ga-68 Generator and Modular Lab system
  • Class 10,000 clean room
  • QC lab with GMP testing equipment
  • Production lab
  • Research labs (2)
  • Space for expansion

Future Directions

  • Develop new probes for PET or SPECT imaging of biomarkers, focusing on cancer, diabetes, heart disease and mental illnesses
  • Synthesize Positron Emitting Radiopharmaceuticals (PERs), optimize their chemistry, and prepare them to GMP specifications for use in humans
  • Validate probes via in vitro experiments and our small animal microPET and microSPECT scanners Verify with large animal imaging on a clinical PET/CT, SPECT/CT or PET/MRI scanner
  • Conduct clinical trials to help translate into clinical practice

We are seeking:

  • Contract Research
  • Long Term Partnership with Industry
  • Clinical Trials
  • Radiopharmaceutical Production

All rights reserved. Lawson Imaging, Lawson Health Research Institute
268 Grosvenor Street, London, Ontario, Canada N6A 4V2
Tel:(519) 646-6100 | Fax:(519) 646-6205